| 货号 | 14615-50mg |
| 描述 | Meclizine is an antagonist of the histamine H1 receptor (Ki = 250 nM).1 Unlike some antihistamines, it has low affinity for muscarinic receptors (Ki = 3.6 nM).2 Meclizine is also a weak agonist of pregnane X receptor (EC50 > 10 µM).3 Because of its actions on the H1 receptor, meclizine reduces nausea, dizziness, and motion sickness.4 The effects of this compound on early development are diverse.5 |
| 别名 | Bonamine;Meclozine;NSC 28728;Parachloramine;Postafen; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Tran, V.T.,Chang, R.S.L. and Snyder, S.H. Histamine H1 receptors identified in mammalian brain membranes with [3H]mepyramine. Proceedings of the National Academy of Sciences of the United States of America 75(12), 6290-6294 (1978). 2.Kubo, N.,Shirakawa, S.,Kuno, T., et al. Antimuscarinic effects of antihistamines: Quantitative evaluation by receptor-binding assay. Japanese Journal of Pharmacology 43(3), 277-282 (1987). 3.Lau, A.J.,Yang, G.,Rajaraman, G., et al. Differential effect of meclizine on the activity of human pregnane X receptor and constitutive androstane receptor. Journal of Pharmacology and Experimental Therapeutics 336(3), 816-826 (2011). 4.Wang, Z.,Lee, B.,Pearce, D., et al. Meclizine metabolism and pharmacokinetics: Formulation on its absorption. Journal of Clinical Pharmacology 52(9), 1343-1349 (2012). 5.Källén, B. and Mottet, I. Delivery outcome after the use of meclozine in early pregnancy. Eur.J.Epidemiol. 18(7), 665-669 (2003). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 463.9 |
| 分子式 | C25H27ClN2 • 2HCl |
| CAS号 | 1104-22-9 |
| 稳定性 | ≥ 2 years |
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