| 货号 | 14177-50mg |
| 描述 | B-HT 920 is a potent agonist of dopamine 2 (D2) receptors (Ki = 5.8 nM) that shows selectivity for D2 over D3 and D4receptors.1,2,3 It has neuroprotective and regenerative effects in animal models of Parkinson’s disease.4 B-HT 920 is also an agonist of α2-adrenergic receptors and an antagonist of serotonin-3 (5-HT3; Ki = 0.35 µM) receptors.5,6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Maina, F.K. and Mathews, T.A. A functional fast scan cyclic voltammetry assay to characterize dopamine D2 and D3 autoreceptors in the mouse striatum. ACS Chem Neurosci. 1(6), 450-462 (2010). 2.Mewshaw, R.E.,Kavanagh, J.J.,Stack, G., et al. New generation dopaminergic agents. 1. Discovery of a novel scaffold which embraces the D2 agonist pharmacophore. Structure-activity relationships of a series of 2-(aminomethyl)chromans. J. Med. Chem. 40(26), 4235-4256 (1997). 3.Robertson, G.S.,Tham, C.S.,Wilson, C., et al. In vivo comparisons of the effects of quinpirole and the putative presynaptic dopaminergic agonists B-HT 920 and SND 919 on striatal dopamine and acetylcholine release. J. Pharmacol. Exp. Ther. 264(3), 1344-1351 (1993). 4.Kitamura, Y. Dopaminergic neuroprotection and reconstruction of neural network tiara. Yakugaku Zasshi 130(10), 1263-1272 (2010). 5.Nishio, H.,Kohno, Y.,Fujii, A., et al. 5-HT3 receptor blocking properties of the antiparkinsonian agent, talipexole. Gen. Pharmcol. 27(5), 778-785 (1996). 6.Rocco, D. and Taira, C.A. Adrenoceptor involvement in the cardiovascular responses to B-HT 920 in sinoaortic denervated rats. Gen. Pharmcol. 32(1), 29-34 (1999). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 282.2 |
| 分子式 | C10H15N3S • 2HCl |
| CAS号 | 36085-73-1 |
| 稳定性 | ≥ 2 years |
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