20-ethyl Prostaglandin F2α
货号：
16940-10mg 基本售价：
5712.0 元 规格：
10 mg
产品信息
概述| 货号 | 16940-10mg |
| 描述 | 20-ethyl Prostaglandin F2α (20-ethyl PGF2α) is an analog of PGF2α in which the ω-chain has been extended by the addition of two more methylene carbon atoms. It is therefore a modified version of the clinically approved glaucoma medication unoprostone.1 Unoprostone also contains lower side chain modifications (13,14-dihydro-15-keto) which severely limit its affinity for FP receptors, contributing to its lack of potency as a medication. 20-ethyl PGF2α retains the natural 15(S) allylic hydroxyl in the lower side chain, which may improve its potency as an intraocular hypotensive agent compared to unoprostone. The 2 carbon extension in 20-ethyl-PGF2α increases the Ki (120 nM) for the FP receptor from bovine corpus luteum only about 2.5-fold compared to PGF2α (50 nM).2In vivo effects may be prolonged using 20-ethyl PGF2α, as the activity of 15-hydroxy PGDH using 20-ethyl PGF2α as a substrate is only 35% of the activity observed with PGF2α.3,2 |
| 别名 | ICI 74205;20-ethyl PGF2α; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Haria, M. and Spencer, C.M. Unoprostone (isopropyl unoprostone). Drugs & Aging 9, 213-218 (1996).
2.Powell, W.S.,Hammarström, S.,Samuelsson, B., et al. Interactions between prostaglandin analogues and a receptor in bovine Corpora lutea. Correlation of dissociation constants with luteolytic potencies in hamsters. European Journal of Biochemistry 59, 271-276 (1975).
3.Sun, F.F.,Armour, S.B.,Bockstanz, V.R., et al. Studies on 15-hydroxyprostaglandin dehydrogenase from monkey lung. Advances in Prostaglandin and Thromboxane Research 1, 163-169 (1976).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 382.5 |
| 分子式 | C22H38O5 |
| CAS号 | 36950-85-3 |
| 稳定性 | ≥ 1 year |
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