17-phenyl trinor Prostaglandin F2α amide
货号：
16821-10mg 基本售价：
5712.0 元 规格：
10 mg
产品信息
概述| 货号 | 16821-10mg |
| 描述 | 17-phenyl trinor Prostaglandin F2α amide (17-phenyl trinor PGF2α amide) is an F-series PG analog in which the C-1 carboxyl group has been modified to an unsubstituted amide. PG esters have been shown to have ocular hypotensive activity.1 PG N-ethyl amides were recently introduced as alternative PG hypotensive prodrugs.2 Although it has been claimed that PG amides are not converted to the free acids in vivo,2 studies have shown that bovine and human corneal tissue converts the amides of various PGs to the free acids with a conversion efficiency of about 10-20% relative to the hydrolysis of isopropyl esters.3 17-phenyl trinor PGF2α amide would be expected to show the typical intraocular effects of latanoprost, but with the much slower hydrolysis pharmacokinetics of the PG N-amides. |
| 别名 | Bimatoprost amide;17-phenyl trinor PGF2αamide; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bito, L.Z. Comparison of the ocular hypotensive efficacy of eicosanoids and related compounds. Experimental Eye Research 38, 181-184 (1984).
2.Woodward, D.F.,Krauss, A.H.P.,Chen, J., et al. The pharmacology of Bimatoprost (Lumigan™). Survey of Ophthalmology 45, S337-S345 (2001).
3.Maxey, K.M.,Johnson, J.,Camras, C.B., et al. The hydrolysis of bimatoprost in corneal tissue generates a potent prostanoid FP receptor agonist. Survey of Ophthalmology 47(4), 34-40 (2002).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 387.5 |
| 分子式 | C23H33NO4 |
| CAS号 | 155205-89-3 |
| 稳定性 | ≥ 1 year |
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