| 货号 | 14940-10mg |
| 描述 | 20-ethyl Prostaglandin E2 (20-ethyl PGE2) is an analog of PGE2 in which the ω-chain has been extended by the addition of two methylene carbon atoms. The only well studied prostaglandin analog with this structural feature is unoprostone, an F-series prostaglandin that is clinically approved as a glaucoma medication.1 Unoprostone also contains lower side chain modifications (13,14-dihydro-15-keto) which severely limit its affinity for FP receptors, contributing to its lack of potency as a medication. 20-ethyl PGE2 retains the natural 15(S) allylic hydroxyl in the lower side chain, which may improve its potency relative to unoprostone. However, ligand binding assays of this analog with respect to EP or other prostanoid receptors have not been published. E-type prostaglandins have been widely reported to have inflammatory,2cytoprotective,3 and a variety of other effects.4 |
| 别名 | 20-ethyl PGE2; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Haria, M. and Spencer, C.M. Unoprostone (isopropyl unoprostone). Drugs & Aging 9, 213-218 (1996). 2.Matsumoto, H.,Naraba, H.,Murakami, M., et al. Concordant induction of prostaglandin E2 synthase with cyclooxygenase-2 leads to preferred production of prostaglandin E2 over thromboxane and prostaglandin D2 in lipopolysaccharide-stimulated rat peritoneal macrophages. Biochemical and Biophysical Research Communications 230, 110-114 (1997). 3.Karim, S.M.M.,Carter, D.C.,Bhana, D., et al. Effect of orally administered prostaglandin E2 and its 15-methyl analogues on gastric secretion. British Medical Journal 1, 143-146 (1973). 4.Jackson, G.M.,Sharp, H.T. and Varner, M.W. Cervical ripening before induction of labor: A randomized trial of prostaglandin E2 gel versus low-dose oxytocin. American Journal of Obstetics and Gynecology 171, 1092-1096 (1994). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥97% |
| 计算分子量 | 380.5 |
| 分子式 | C22H36O5 |
| CAS号 | 37492-24-3 |
| 稳定性 | ≥ 1 year |
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