| 货号 | 14210-10mg |
| 描述 | 5-transPGE2 occurs naturally in some gorgonian corals and is a common impurity in commercial lots of PGE1.1 It is 18 times more potent than PGE2 in activating adenylate cyclase in NCB-20 cell homogenates.25-transPGE2 accelerates fibrinolysis by enhancing plasminogen activation mediated by tissue-type plasminogen activator.3 It also inhibits platelet aggregation in human PRP with an IC50 of 180 nM.4 |
| 别名 | trans-Dinoprostone;5,6-transPGE2; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bundy, G.L.,Schneider, W.P.,Lincoln, F.H., et al. Isolation of a new naturally occurring prostaglandin, 5-trans-PGA2. Synthesis of 5-trans-PGE2 and 5-trans-PGF2α. Journal of the American Chemical Society 94, 2124 (1972). 2.Hensby, C.N. and MacDermot, J. Structure-activity relationships of prostanoids that activate adenylate cyclase of neuronal hybrid cells. Biochemical Society Transactions 7, 1302-1304 (1979). 3.Shimokawa, M.,Urano, T. and Kinoshita, T. trans-5-Prostaglandin E2 stimulates plasminogen activation by tissue-type plasminogen activator. Biochimica et Biophysica Acta 1137, 317-320 (1992). 4.Kobzar, G.,Mardla, V.,Järving, I., et al. Comparison of the inhibitory effect of E-prostaglandins in human and rabbit platelet-rich plasma and washed platelets. Comparative Biochemistry and Physiology 106(2), 489-494 (1993). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 352.5 |
| 分子式 | C20H32O5 |
| CAS号 | 36150-00-2 |
| 稳定性 | ≥ 2 years |
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