Propenyl-L-NIO (hydrochloride)
货号：
10011724-50mg 基本售价：
5712.0 元 规格：
50 mg
产品信息
概述| 货号 | 10011724-50mg |
| 描述 | Propenyl-L-NIO (hydrochloride) (ENIPO) is a potent, selective inhibitor of iNOS. The Ki values for inhibition of iNOS, nNOS, and eNOS by ENIPO are 17, 10.3 and 58.2 µM, respectively, as determined using initial rate binding kinetics.1 However, ENIPO is a time-dependent inhibitor that, with longer incubations, demonstrates reversible tight binding inhibition that is selective for iNOS over nNOS or eNOS. This selectivity results from iNOS exhibiting a 4-fold faster binding and 10-fold slower dissociation with ENIPO compared to nNOS.1Ki values for ENIPO binding to iNOS and nNOS are 0.56 and 6 µM, respectively.1 Accurate determination of the Ki value of ENIPO for eNOS has not been determined but is expected to be 50-fold less than iNOS.1 |
| 别名 | ENIPO; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bretscher, L.E.,Li, H.,Poulos, T.L., et al. Structural characterization and kinetics of nitric-oxide synthase inhibition by novel N5-(iminoalkyl)- and N5-(iminoalkenyl)-ornithines. The Journal of Biological Chemisty 278(47), 46789-46797 (2003).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥90% |
| 计算分子量 | 249.7 |
| 分子式 | C10H19N3O2 • HCl |
| 稳定性 | ≥ 2 years |
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