| 货号 | 0925/50 |
| 别名 | (R)-(+)-7-Chloro-8-hydroxy-3-methyl |
| 供应商 | Tocris |
| 生物活性 | Potent dopamine receptor antagonist (Ki values are 0.2 nM and 0.3 nM at D1 and D5 receptor sub-types, respectively). Also an agonist at 5-HT1C and 5-HT2Creceptorsin vitro(Ki values are 6.3 nM and 9.3 nM respectively). Blocks quinpirole-induced Kir3 (GIRK) currents (EC50 = 268 nM) independently of receptors. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 324.24 |
| 分子式 | C17H18ClNO.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water with gentle warming and to 50 mM in ethanol |
| CAS号 | 125941-87-9 |
| 参考文献 | Kuzhikandathil and Oxford (2002) Classic D1 dopamine receptor antagonist R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (SCH23390) directly inhibits G protein-coupled inwardly rectifying potassium channels. Mol.Pharmacol. 62 119. PMID: 12065762. Bourneet al (2001) SCH 23390: The first selective dopamine D1-like receptor antagonist. CNS Drug Rev. 7 399. PMID: 11830757. Millanet al (2001) The "selective" dopamine D1 receptor antagonist, SCH23390, is a potent and high efficacy agonist against cloned human serotonin2C receptors. Psychopharmacology 156 58. PMID: 11465634. Briggset al (1991) Activation of the 5-HT1C receptor expressed in Xenopus oocytes by the benzazepines SCH 23390 and SKF 38393. Br.J.Pharmacol. 104 1038. PMID: 1687364. |