| 货号 | 10803-100ug |
| 描述 | Autotaxin (ATX) is a secreted lysophospholipase D that catalyzes the hydrolysis of lysophosphatidylcholine (LPC) to generate lysophosphatidic acid (LPA). LPA is a lipid mediator that activates G protein-coupled receptors and induces various cellular responses.1 ATX-LPA signaling is involved in a range of pathologies including tumor progression and inflammation.2 ATX is proteolytically processed by cleavage of a 35 amino acid signal peptide and then secreted as a mature protein.3 N-glycosylation of ATX at Asn53 and Asn410 is essential for activity and secretion of ATX from adipocytes.1 ATX is organized in a modular domain arrangement with a central phosphodiesterase catalytic site, which is similar to the catalytic domain of alkaline phosphatases.4 Two cysteine-rich somatomedin B-like domains (involved in protein-protein interactions) are located at the N-terminal portion of the protein followed by an adjacent hydrophobic-containing RGD tripeptide motif that may be involved in cell-extracellular matrix interactions. Finally, a nuclease-like domain is located at the C-terminus, which is catalytically inert and possibly involved in substrate binding and presentation.5 |
| 别名 | Ectonucleotide Pyrophosphatase/Phosphodiesterase-2;ENPP-2;Lysophospholipase D; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Boutin, J.A. and Ferry, G. Autotaxin. Cellular and Molecular Life Sciences 66, 3009-3021 (2011). 2.Nam, S.W.,Clair, T.,Campo, C.K., et al. Autotaxin (ATX), a potent tumor motogen, augments invasive and metastatic potential of ras-transformed cells. Oncogene 19, 241-247 (2011). 3.Jansen, S.,Stefan, C.,Creemers, J.W.M., et al. Proteolytic maturation and activation of autotaxin (NPP2), a secreted metastasis-enhancing lysophospholipase D. Journal of Cell Science 118(14), 3081-3089 (2011). 4.Nishimasu, H.,Okudaira, S.,Hama, K., et al. Crystal structure of autotaxin and insight into GPCR activation by lipid mediators. Nature Structural & Molecular Biology 18(2), 205-212 (2011). 5.Hausmann, J.,Kamtekar, S.,Christodoulou, E., et al. Structural basis of substrate discrimination and integrin binding by autotaxin. Nature Structural & Molecular Biology 18(2), 198-204 (2011). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥95% estimated by SDS-PAGE |
| 稳定性 | ≥ 9 months |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |