TIP60 (human recombinant)
货号：
10783-100ug 基本售价：
5670.0 元 规格：
100 ug
产品信息
概述| 货号 | 10783-100ug |
| 描述 | TIP60 is a member of the MYST family of lysine acetyl transferases. It has been shown to acetylate histones, p53, and the Ataxia Telangiectasia Mutant (ATM) protein kinase.1 As a component of the TIP60-p400 complex, TIP60 acetylates transcription repressors in order to inhibit gene transcription.2 In complexes without p400, TIP60 is part of a chromatin remodeling complex which plays an important role in double-stranded DNA break repair. Acetylation of histone γH2AX allows formation of the γH2AX repair foci, and acetylation of ATM is one of the early steps in double-stranded DNA break repair. Furthermore, TIP60 is bound by the cytoplasmic tail of β-amyloid precursor protein which drives gene transcription, apoptosis, and potentially a role in Alzheimer’s disease pathogenesis.3 |
| 别名 | cPLA(2) Interacting Protein;Esa1;HIV-1 Tat Interacting Protein 60 kDa;Hs.6364;HTATIP;KAT5;PLIP; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sun, Y.,Jiang, X. and Price, B.D. Tip60: Connecting chromatin to DNA damage signaling. Cell Cycle 9(5), 930-936 (2010).
2.Fazzio, T.G.,Hurr, J.T. and Panning, B. Chromatin regulation Tip(60)s the balance in embryonic stem cell self-renewal. Cell Cycle 7(21), 3302-3306 (2008).
3.Wu, J.,Wang, J.,Li, M., et al. Small molecule inhibitors of histone acetyltransferase Tip60. Bioorganic Chemistry 39(1), 53-58 (2011).
|
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 稳定性 | ≥ 6 months |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
