| 货号 | 20150-100ug |
| 描述 | Leukotriene B4(LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway.1,2 It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis.3,4 At least two LTB4 receptors, termed BLT1 and BLT2, have been identified. 14,15-dehydro LTB4 is a LTB4 receptor antagonist that has a higher binding affinity for BLT1, demonstrating a Ki value of 27 nM, compared to BLT2, which has a Ki value of 473 nM.5 14,15-dehydro LTB4 inhibits LTB4-induced release of lysozymes from rat polymorphonuclear leukoctyes with an IC50 value of 1 µM.6 |
| 别名 | 14,15-dehydro LTB4; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Rådmark, O.,Malmsten, C.,Samuelsson, B., et al. Leukotriene A: Stereochemistry and enzymatic conversion to leukotriene B. Biochemical and Biophysical Research Communications 92, 954-961 (1980). 2.McGee, J. and Fitzpatrick, F. Enzymatic hydration of leukotriene A4. The Journal of Biological Chemisty 260, 12832-12837 (1985). 3.Ford-Hutchinson, A.W. Leukotriene B4 in inflammation. Critical Reviews in Immunology 10, 1-12 (1990). 4.McMillan, R.M. and Foster, S.J. Leukotriene B4 and inflammatory disease. Agents and Actions 24, 114-119 (1988). 5.Wang, S.,Gustafson, E.,Pang, L., et al. A novel hepatointestinal leukotriene B4 receptor. The Journal of Biological Chemisty 275, 40686-40694 (2000). 6.Shimazaki, T.,Kobayashi, Y.,Sato, F., et al. Some newly synthesized leukotriene B4 analogs inhibit LTB4-induced lysozyme release from rat polymorphonuclear leukocytes. Prostaglandins 39, 459-467 (1990). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥97% |
| 计算分子量 | 334.5 |
| 分子式 | C20H30O4 |
| CAS号 | 114616-11-4 |
| 稳定性 | ≥ 1 year |
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