Leukotriene B4 Ethanolamide
货号：
20112-100ug 基本售价：
5642.0 元 规格：
100 ug
产品信息
概述| 货号 | 20112-100ug |
| 描述 | The effects of Leukotriene B4(LTB4) are mediated by two known receptors, BLT1 and BLT2.1,2LTB4 is a high affinity ligand for BLT1, and many of its pro-inflammatory effects are believed to be transduced through this receptor. The BLT2 is more enigmatic, in that LTB4 is not a high-affinity ligand, nor is it clear that BLT2 activation promotes inflammation. LTB4 ethanolamide (LTB4-EA) is a theoretical 5-LO metabolite of arachidonoyl ethanolamide (AEA). In CHO cells transfected with human BLTR1, LTB4-EA was a potent antagonist with about three times greater affinity for the receptor than LTB4(Ki = 1.22 nM versus 3.88 nM). LTB4-EA antagonizes the LTB4-induced contractions of guinea pig lung parenchyma with an EC50 of 10 nM.3LTB4-EA thus represents a potential endogenous anti-inflammatory compound functioning as a natural antagonist of BLTR1. |
| 别名 | LTB4-EA; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Yokomizo, T.,Izumi, T.,Chang, K., et al. A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis. Nature 387, 620-624 (1997).
2.Yokomizo, T.,Kato, K.,Terawaki, K., et al. A second leukotriene B4 receptor, BLT2: A new therapeutic target in inflammation and immunological disorders. Journal of Experimental Medicine 193, 421-431 (2000).
3.McHugh, D.,McMaster, S. and Ross, R. Pharmacological characterization of LTB4 ethanolamide: Interaction with leukotriene (BLT) and vanilloid (TRPV1) receptors. 121-121.
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥97% |
| 计算分子量 | 379.5 |
| 分子式 | C22H37NO4 |
| CAS号 | 877459-63-7 |
| 稳定性 | ≥ 1 year |
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