| 货号 | 3522/1 |
| 供应商 | Tocris |
| 生物活性 | Endogenous peptide secreted from cardiac ventricles in response to volume increase and pressure overload that acts as an agonist at atrial natriuretic peptide (ANP) receptor A (NRP1). Decreases de novo collagen synthesis and increases MMP gene expression in vitro. Exhibits natriuretic, vasodilatory and lusitropic activity and inhibits the sympathetic and renin-angiotensin-aldosterone systems in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 3464.05 |
| 分子式 | C143H224N50O42S4 |
| 可溶性/溶解性 | Soluble to 0.10 mg/ml in water |
| CAS号 | 124584-08-3 |
| 序列号 | SPKMVQGSGCFGRKMDRISSSSGLGCKVLR (Modifications: Disulfide bridge between 10 - 26) |
| 参考文献 | Heubleinet al (2007) Immunoreactivity and guanosine 3',5'-cyclic monophosphate activating actions of various forms of human B-type natriuretic peptide. Hypertension 49 1114. PMID: 17372040. Wellardet al (2006) Natriuretic peptides, but not nitric oxide donors, elevate levels of cytosolic guanosine 3',5'-cyclic monophosphate in ependymal cells ex vivo. Neurosci.Lett. 392 187. PMID: 16278044. Tsurudaet al (2002) Brain natriuretic peptide is produced in cardiac fibroblasts and induces matrix metalloproteinases. Circ.Res. 91 1127. PMID: 12480813. |