| 货号 | 4706/1 |
| 别名 | (1R,2R)-2-[(2S,4E,6Z,8R,9S,11R,13S, |
| 供应商 | Tocris |
| 生物活性 | Antibiotic and antiangiogenic. Selectively inhibits threonyl-tRNA synthetase (ThrRS). Exhibits antiangiogenic activity in a mouse model of tumor angiogenesis. Induces apoptosis in capillary tube-forming endothelial cells; disrupts capillary tubes and inhibits their formation (IC50 = 0.8 nM in rat aorta). Induces the unfolded protein response (UPR) and apoptosis in oral cancer cells. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 489.64 |
| 分子式 | C28H43NO6 |
| 可溶性/溶解性 | Soluble to 2 mM in DMSO |
| 参考文献 | Sidhuet al (2015) Borrelidin induces the unfolded protein response in oral cancer cells and Chop-dependent apoptosis. ACS Med.Chem.Lett. 6 1122. PMID: 26617965. Woolardet al (2011) Borrelidin modulates the alterntive splicing of VEGF in favour of anti-antiogenic isoforms. Chem.Sci. (2) 273. PMID: 22822423. Kawamuraet al (2003) Anti-angiogenesis effect of borrelidin are mediated through distinct pathways: threonyl-tRNA synthetase and caspases are independently involved in suppression of proliferation and induction of apoptosis in endothelial cells. J.Antibiot.(Tokyo). 56 709. PMID: 14563161. Wakabayashiet al (1997) Borrelidin is an angiogenesis inhibitor; disruption of angiogenic capillary vessels in a rat aorta matrix culture model. J.Antibiot.(Tokyo). 50 671. PMID: 9315080. |