Caspase-3/7 Inhibitor I
货号：
14464-5mg 基本售价：
5600.0 元 规格：
5 mg
产品信息
概述| 货号 | 14464-5mg |
| 描述 | Caspase-3/7 inhibitor I is a potent, reversible, isatin sulfonamide-based inhibitor of caspase-3 (Ki(app) = 60 nM; IC50 = 120 nM) and caspase-7 (Ki(app) = 170 nM).1 It is a weaker inhibitor of caspase-9 (Ki(app) = 3.1 μM) and caspase-1, caspase-2, caspase-4, caspase-6, and caspase-8 (Ki(app)s ≥25 μM).1,2 Caspase-3/7 inhibitor I inhibits apoptosis in camptothecin-treated Jurkat cells (IC50 = ~50 µM) and in chondrocytes (44% inhibition at 10 µM and 98% inhibition at 50 µM).2 The basis for the unique selectivity of this compound for caspases 3 and 7 involves the recognition of three distinct hydrophobic residues in the S2 pocket surrounding the catalytic cysteine residue.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lee, D.,Long, S.A.,Adams, J.L., et al. Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality. The Journal of Biological Chemisty 275, 16007-16014 (2000).
2.Lee, D.,Long, S.A.,Murray, J.H., et al. Potent and selective nonpeptide inhibitors of caspases 3 and 7. Journal of Medicinal Chemistry 44, 2015-2026 (2001).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 324.4 |
| 分子式 | C14H16N2O5S |
| CAS号 | 1110670-49-9 |
| 稳定性 | ≥ 2 years |
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