5-hydroxy Omeprazole
货号：
10009028-1mg 基本售价：
5600.0 元 规格：
1 mg
产品信息
概述| 货号 | 10009028-1mg |
| 描述 | 5-hydroxy Omeprazole is a major metabolite of omeprazole (Item No. 14880), an inhibitor of the gastric H+/K+-ATPase pump.1 5-hydroxy Omeprazole is produced from omeprazole by the action of cytochrome P450 (CYP) isoform 2C19, a monooxygenase.2,3 CYP2C19 polymorphisms significantly influence the metabolism of omeprazole, and individuals may be classified as homozygous extensive metabolizers, heterozygous extensive metabolizers, and poor metabolizers.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Shi, S., and Klotz, U. Proton pump inhibitors: An update of their clinical use and pharmacokinetics. Eur. J. Clin. Pharmacol. 64, 935-951 (2008).
2.Abelö, A.,Andersson, T.B.,Antonsson, M., et al. Stereoselective metabolism of omeprazole by human cytochrome P450 enzymes. Drug Metab. Dispos. 28(8), 966-972 (2000).
3.Karam, W.G.,Goldstein, J.A.,Lasker, J.M., et al. Human CYP2C19 is a major omeprazole 5-hydroxylase, as demonstrated with recombinant cytochrome P450 enzymes. Drug Metab. Dispos. 24, 1081-1087 (1996).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 361.4 |
| 分子式 | C17H19N3O4S |
| CAS号 | 92340-57-3 |
| 稳定性 | ≥ 3 years |
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