| 货号 | 10007448-1mg |
| 描述 | Triacsin C, originally isolated from Streptomyces sp., is an inhibitor of long fatty acid acyl-CoA synthetase (IC50 = 6.3 μM in Raji cells).1 It has been shown to interfere with lipid metabolism by inhibiting the de novo synthesis of triglycerides, diglycerides, and cholesterol esters.2 It is also known to act as a hypotensive vasodilator, modulating endothelial nitric oxide synthase repalmitoylation by limiting palmitoyl CoA availability.3 Triacsin C can inhibit pancreatic β-cell function by suppressing the mobilization of intracellular calcium.4 |
| 别名 | FR900190;WS1228A; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Tomoda, H.,Igarashi, K.,Cyong, J.C., et al. Evidence for an essential role of long chain acyl-CoA synthetase in animal cell proliferation. Inhibition of long chain acyl-CoA synthetase by triacsins caused inhibition of Raji cell proliferation. The Journal of Biological Chemisty 266, 4214-4219 (1991). 2.Igal, R.A.,Wang, P., and Coleman, R.A. Triacsin C blocks de novo synthesis of glycerolipids and cholesterol esters but not recycling of fatty acid into phospholipid: Evidence for functionally separate pools of acyl-CoA. Biochemistry Journal 324(Pt 2), 529-534 (1997). 3.Weis, M.T.,Crumley, J.L.,Young, L.H., et al. Inhibiting long chain fatty acyl CoA synthetase increases basal and agonist-stimulated NO synthesis in endothelium. Cardiovascular Research 63(2), 338-346 (2004). 4.Zhao, Y.,Wang, L.,Qiu, J., et al. Linoleic acid stimulates [Ca2+]i increase in rat pancreaticβcells through both membrane receptor- and intracellular metabolite-mediated pathways. PLoS One 8(4), e60255 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 207.3 |
| 分子式 | C11H17N3O |
| CAS号 | 76896-80-5 |
| 稳定性 | ≥ 2 years |
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