| 货号 | 2373/50 |
| 别名 | N-(2,2,2-Trifluoroethyl)-N-[4-[2,2, |
| 供应商 | Tocris |
| 生物活性 | Potent, high affinity liver X receptor (LXR) agonist (EC50 ~ 50 nM, Kd values are 7 and 22 nM for LXR-α and LXR-β respectively). Upregulates expression of the ABCA1 gene associated with cholesterol efflux regulation and HDL metabolism. Decreases amyloid-β production in primary neurons in vitro. Displays an EC50 of ~ 5 μM for activation of bile acid farnesoid X receptors (FXRs); 10-fold more potent than natural FXR ligand chenodeoxycholic acid. Also exhibits inverse agonist activity at constitutive androstane receptors (CAR). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 481.33 |
| 分子式 | C17H12F9NO3S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| CAS号 | 293754-55-9 |
| 参考文献 | Kannoet al (2013) T0901317, a potent LXR agonist, is an inverse agonist of CAR. J.Toxicol.Sci. 38 309. PMID: 23665929. Mitroet al (2007) The nuclear receptor LXR is a glucose sensor. Nature Lett. 445219. Koldamovaet al (2005) The liver X receptor ligand T0901317 decreases amyloid β production in vitro and in a mouse model of Alzheimer's disease. J.Biol.Chem. 280 4079. PMID: 15557325. Houcket al (2004) T0901317 is a dual LXR/FXR agonist. Mol.Gen.Metab. 83184. Repaet al (2000) Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science 289 1524. PMID: 10968783. |