| 货号 | 2719/50 |
| 别名 | 7,8-Dihydro-8-oxo-7-(2-propenyl)gua |
| 供应商 | Tocris |
| 生物活性 | Toll-like receptor 7 (TLR7) agonist; induces immune cell activation and increases cytokine production. Displays antitumor and antiviral activity in various animal models. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >97 % |
| 计算分子量 | 339.3 |
| 分子式 | C13H17N5O6 |
| 可溶性/溶解性 | Soluble to 20 mM in water and to 75 mM in DMSO |
| CAS号 | 121288-39-9 |
| 参考文献 | Heilet al (2003) The toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur.J.Immunol. 33 2987. PMID: 14579267. Leeet al (2003) Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of toll-like receptor 7. Proc.Natl.Acad.Sci.USA 100 6646. PMID: 12738885. Goodmanet al (1994) Loxoribine induces chronic lymphocytic leukemia B cells to traverse the cell cycle. Blood 84 3457. PMID: 7949100. |