| 货号 | 4482/50 |
| 别名 | 2,6-Diamino-3,5-dithiocyanopyridine |
| 供应商 | Tocris |
| 生物活性 | Broad spectrum, reversible DUB inhibitor. Exhibits limited activity against other proteases. Induces accumulation of polyubiquitinated proteins, but has no direct inhibitory effect on the proteasome. Cytotoxic in HEK293T and colorectal cancer cells. Stabilizes microtubule network in oligodendroglial cells. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 223.28 |
| 分子式 | C7H5N5S2 |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO |
| 参考文献 | Seiberlichet al (2012) The small molecule inhibitor PR-619 of deubiquitinating enzymes affects the microtubule network and causes protein aggregate formation in neural cells: implications for neurodegenerative diseases. Biochim.Biophys.Acta 1823 2057. PMID: 22565157. Altunet al (2011) Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. Chem.Biol. 18 1401. PMID: 22118674. |