| 货号 | 4287/50 |
| 别名 | Polyinosinic-polycytidylic acid sodium salt |
| 供应商 | Tocris |
| 生物活性 | Synthetic double-stranded RNA (dsRNA); Toll-like receptor 3 (TLR3) agonist. Aids generation of stable, mature dendritic cells. Transfection into NIT-1 β cells induces β-cell apoptosis. Immunostimulant. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 分子式 | (C10H13N4O8P) |
| 可溶性/溶解性 | Soluble to 3 mg/ml in water |
| 参考文献 | Westet al (2011) TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature 472 476. PMID: 21525932. Rouaset al (2004) Poly(I:C) used for human dendritic cell maturation preserves their ability to secondarily secrete bioactive IL-12. Int.Immunol. 16 767. PMID: 15096480. Robbinset al (2003) Nuclear factor-κB translocation mediates double-stranded ribonucleic acid-induced NIT-1 beta-cell apoptosis and up-regulates caspase-12 and tumor necrosis factor-associated ligand (TRAIL). Endocrinology 144 4616. PMID: 12960048. |