| 货号 | 0670/50 |
| 别名 | 1-(2-Chlorophenyl)-N-methyl-N-(1-me |
| 供应商 | Tocris |
| 生物活性 | Possesses high affinity for the peripheral benzodiazepine receptor (PBR, TSPO) without binding to other known neurotransmitter receptors. Also inhibits the human constitutive androstane receptor (hCAR). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 352.86 |
| 分子式 | C21H21ClN2O |
| 可溶性/溶解性 | Soluble to 50 mM in ethanol and to 50 mM in DMSO |
| CAS号 | 85532-75-8 |
| 参考文献 | Liet al (2008) The peripheral benzodiazepine receptor ligand 1-(2-chlorophenyl-methylpropyl)-3-isoquinoline-carboxamide is a novel antagonist of human androstane receptor. Mol.Pharmacol. 74 443. PMID: 18492798. Conwayet al (1998) Temporal changes in glial fibrillary acidic protein messenger RNA and [3H]PK11195 binding in relation to imidazoline-I2-receptor and α2-adrenoceptor binding in the hippocampus following transient global forebrain ischaemia in the rat. Neuroscience 82 805. PMID: 9483537. Le Furet al (1983) Differentiation between two ligands for peripheral benzodiazpine binding sites [3H]-Ro 5-4864 and [3H]-PK11195, by thermodynamic studies. Life Sci. 33 449. PMID: 6308375. |