| 货号 | 2653/50 |
| 别名 | 2-Phenylethynesulfonamide; NSC 303580 |
| 供应商 | Tocris |
| 生物活性 | Inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. Displays no effect on the transactivational or cell cycle checkpoint control function of p53. Potentially increases reprogramming efficiency of human somatic cells to induced pluripotent stem cells (iPSCs) by silencing p53. Reduces cell death induced by γ-radiationin vitro and protects mice from doses of radiation that cause lethal hematopoietic syndrome. Selectively inhibits heat shock protein 70 (HSP70) activity. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 181.21 |
| 分子式 | C8H7NO2S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| CAS号 | 64984-31-2 |
| 参考文献 | Kawamuraet al (2009) Linking the p53 tumor suppressor pathway to somatic cell reprogramming. Nature 460 1140. PMID: 19668186. Leuet al (2009) A small molecule inhibitor of inducible heat shock protein 70 (HSP70). Mol.Cell 36 15. PMID: 19818706. Steeleet al (2009) 2-phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells. Blood 114 1217. PMID: 19515722. Stromet al (2006) Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation. Nat.Chem.Biol. 2 474. PMID: 16862141. |