| 货号 | 0879/50 |
| 别名 | N-(2-Hydroxyethyl)hexadecanamide; PEA |
| 供应商 | Tocris |
| 生物活性 | Endogenous lipid that acts as a selective GPR55 agonist (EC50 values are 4, 19 800 and > 30 000 nM at GPR55, CB2 and CB1 receptors respectively). Substrate for fatty acid amide hydrolase (FAAH) and PEA-preferring acid amidase (PAA) and exhibits antinociceptive and anticonvulsant in vivo. Directly activates PPARα(EC50 = 3 μM) producing robust anti-inflammatory actions. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 计算分子量 | 299.5 |
| 分子式 | C18N37NO2 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO and to 25 mM in ethanol |
| CAS号 | 544-31-0 |
| 参考文献 | Ryberget al (2007) The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 152 1092. PMID: 17876302. Lo Vermeet al (2005) The search for the palmitoylethanolamide receptor. Life Sci. 77 1685. PMID: 15963531. Reet al (2005) Palmitoylethanolamide, endocannabinoids and related cannabimimetic compounds in protection against tissue inflammation and pain: potential use in companion animals. Vet.J. 173 21. PMID: 16324856. Lambertet al (2002) The palmitoylethanolamide family: a new class of anti-inflammatory agents? Curr.Med.Chem. 9 663. PMID: 11945130. Lambertet al (2001) Anticonvulsant activity of N-palmitoylethanolamide, a putative endocannabinoid, in mice. Epilepsia 42 321. PMID: 11442148. |