| 货号 | 1484/50 |
| 别名 | (9Z)-N-(2-Hydroxyethyl)-9-octadecen |
| 供应商 | Tocris |
| 生物活性 | Lipid mediator and analog of anandamide (Cat. No. 1339) that is involved in peripheral regulation of feeding. Selective GPR55 agonist (EC50 values are 0.44, >30 and >30 μM at GPR55, CB1 and CB2 respectively) and PPARα agonist (EC50 = 120 nM). Induces satiety through activation of PPARα and is also a ceramidase inhibitor. Also endogenous agonist at the GPR119 receptor. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 325.53 |
| 分子式 | C20H39NO2 |
| CAS号 | 111-58-0 |
| 参考文献 | Ryberget al (2007) The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 152 1092. PMID: 17876302. Fuet al (2003) Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α. Nature 425 90. PMID: 12955147. Calignanoet al (2001) Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide. Eur.J.Pharmacol. 419 191. PMID: 11426841. de Fonsecaet al (2001) An anorexic lipid mediator regulated by feeding. Nature 414 209. PMID: 11700558. Coroneoset al (1995) Differential regulation of sphingomyelinase and ceramidase activities by growth factors and cytokines. J.Biol.Chem. 270 23305. PMID: 7559485. |