| 货号 | 3982/50 |
| 别名 | 3-(2,4-Dichloro-5-methoxyphenyl)-2, |
| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of Dnm1 GTPase (IC50 = 1 - 10 μM); attenuates Dnm1- and Drp1-mediated mitochondrial division. Inhibits mitochondrial outer membrane permeabilization (MOMP) and attenuates apoptosis. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 353.22 |
| 分子式 | C25H10Cl2N2O2S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 338967-87-6 |
| 参考文献 | Lackneret al (2010) Small molecule inhibitors of mitochondrial division: tools that translate basic biological research into medicine. Chem.Biol. 17 57. PMID: 20142041. Cassidy-Stoneet al (2008) Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Develop.Cell 14193. Tanaka and Youle (2008) A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis. Mol.Cell 29 409. PMID: 18313377. |