| 货号 | 1530/50 |
| 别名 | (2S)-(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a |
| 供应商 | Tocris |
| 生物活性 | Potent, competitive inhibitor of HMG-CoA reductase (Ki = 0.6 nM) therefore decreases cholesterol biosynthesis, in vitroandin vivo. Decreases CDK2, 4, 6 and cyclin E levels and induces G1 arrest and apoptosis in tumor cell lines in vitro. Inactive lactam prodrug of lovastatin hydroxy acid, naturally bioactivated in vivo following oral administration. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 404.54 |
| 分子式 | C24H36O5 |
| 可溶性/溶解性 | Soluble to 50 mM in ethanol with gentle warming and to 100 mM in DMSO |
| CAS号 | 75330-75-5 |
| 参考文献 | Parket al (1999) Lovastatin-induced inhibition of HL-60 cell proliferation via cell cycle arrest and apoptosis. Anticancer Res. 19 3133. PMID: 10652602. Alberts (1988) Discovery, biochemistry and biology of lovastatin. Am.J.Cardiol. 62 10J. PMID: 3055919. Albertset al (1980) Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proc.Natl.Acad.Sci.U.S.A. 77 3957. PMID: 6933445. |