| 货号 | 4324/50 |
| 别名 | N,N'-(Dithiodi-2,1-ethanediyl)bis[2, |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of HIF-1α. Thought to act via down-regulation of HIF-1α protein synthesis; reduces phosphorylation of eIF4E binding protein 1 (4EBP1) and p70 S6K in hypoxic conditions. Also blocks hypoxia-induced HIF-1α accumulation in a range of human cancer cell lines. Inhibits the expression of HIF target genes, such as carbonic anhydrase IX and MMP2. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 570.38 |
| 分子式 | C16H16Cl4N2< |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Kohet al (2009) Inhibiting the hypoxia response for cancer therapy: the new kid on the block. Clin.Cancer Res. 15 5945. PMID: 19789327. Naritaet al (2009) Identification of a novel small molecule HIF-1α translation inhibitor. Clin.Cancer Res. 15 6128. PMID: 19789328. |