| 货号 | 3917/50 |
| 别名 | N-(1-Oxodecyl)-L-tryptophyl-D-aspar |
| 供应商 | Tocris |
| 生物活性 | Lipopeptide, calcium-dependent antibiotic. Exhibits potent bacteriocidal activity against most gram-positive bacteria in vitroandin vivo, including antibiotic-resistant strains such as MRSA and VRE. Disrupts plasma membrane function; activity results in membrane depolarization leading to inhibition of protein, DNA and RNA synthesis. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >95 % |
| 计算分子量 | 1620.67 |
| 分子式 | C72H101N17O26 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 20 mM in water |
| CAS号 | 103060-53-3 |
| 参考文献 | Robbel and Marahiel (2010) Daptomycin, a bacterial lipopeptide synthesized by a non-ribosomal machinery. J.Biol.Chem. 285 27501. PMID: 20522545. Steenbergenet al (2005) Daptomycin: a lipopeptide antibiotic for the treatment of serious gram-positive infections. J.Antimicrob Chemother. 55 283. PMID: 15705644. Junget al (2004) Structural transitions as determinants of the action of the calcium-dependent antibiotic daptomycin. Chem.Biol. 11 949. PMID: 15271353. Tally and DeBruin (2000) Development of daptomycin for gram-positive infections. J.Antimicrob Chemother. 46 523. PMID: 11020247. |