| 货号 | 5320/50 |
| 别名 | Tricarbonylchloro(glycinato)rutheni |
| 供应商 | Tocris |
| 生物活性 | Water-soluble carbon monoxide-releasing molecule. Suppresses thrombin-induced nitrite release in BV-2 microglia. Protects isolated rats hearts from reperfusion damage in vitro and is cardioprotective in a rat myocardial infarction model in vivo. Also prolongs survival of transplanted hearts in mice. Exhibits anti-inflammatory and vasorelaxant effects. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 294.61 |
| 分子式 | C5H4ClNO5Ru |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| 参考文献 | Filippoet al (2012) Acute myocardial infarction in streptozotocin-induced hyperglycaemic rats: protection by a carbon monoxide-releasing molecule (CORM-3). Naunyn Schmiedebergs Arch.Pharmacol. 385 137. PMID: 22038495. Bani-Haniet al (2006) Modulation of thrombin-induced neuroinflammation in BV-2 microglia by carbon monoxide-releasing molecule 3. J.Pharmacol.Exp.Ther. 318 1315. PMID: 16772536. Sawleet al (2005) Carbon monoxide-releasing molecules (CO-RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages. Br.J.Pharmacol. 145 800. PMID: 15880142. Forestiet al (2004) Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule. Br.J.Pharmacol. 142 453. PMID: 15148243. Clarket al (2003) Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule. Circ.Res. 93 e2. PMID: 12842916. |