| 货号 | 5371/50 |
| 别名 | 1-[(4-Chlorophenyl)methyl]-2-(1-pyr |
| 供应商 | Tocris |
| 生物活性 | TRPC5 channel blocker (IC50 values are 1.1, 6.4, 9.1, 11.3 and 26.5 μM for TRPC5, TRPC4, TRPC3, TRPC6 and TRPC7 respectively). Exhibits minimal effect on TRPM3, TRPM8 and TRPV1-4 channels. Also histamine H1 receptor antagonist and anticonvulsant in zebrafish Dravet syndrome model. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 362.3 |
| 分子式 | C19H20ClN3. HCl |
| 可溶性/溶解性 | Soluble to 20 mM in water and to 50 mM in DMSO |
| 参考文献 | Richteret al (2014) Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol.Pharm. 86 514. PMID: 25140002. Barabanet al (2013) Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nat.Commun. 4 2410. PMID: 24002024. Aguilaret al (1986) Pharmacological investigation into the effects of histamine and histamine analogues on guinea-pig and rat colon in vitro. Br.J.Pharmacol. 88 501. PMID: 3742147. |