| 货号 | 5399/50 |
| 别名 | 4-Chloro-2-nitro-1-(phenylsulfonyl) |
| 供应商 | Tocris |
| 生物活性 | Selective and ATP-competitive mitotic kinesin Kif18A inhibitor (IC50 = 1.7 μM); reversibly inhibits microtubule-stimulated Kif18A ATPase activity. Displays selectivity against a panel of other mitotic kinesins. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 297.71 |
| 分子式 | C12H8ClNO4S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 20 mM in ethanol |
| 参考文献 | Braunet al (2014) Synthesis and biological evaluation of optimized Inhibitors of the mitotic kinesin Kif18A. ACS Chem.Biol. 10 554. PMID: 25402598. Catarinellaet al (2009) BTB-1: a small molecule inhibitor of the mitotic motor protein Kif18A. Angew.Chem.Int.Ed.Engl. 48 9072. PMID: 19856362. |