| 货号 | 1777/50 |
| 别名 | (3R,4R)-4-[(3,4-Dimethoxyphenyl)met |
| 供应商 | Tocris |
| 生物活性 | Antioxidant, anti-inflammatory, antiproliferative and antiviral agent. Inhibits LPS-induced iNOS expression via inhibition of IκBα phosphorylation and p65 nuclear translocation (IC50 = 10 nM). Inhibits HIV-1 replication in vitro. Also potently inhibits MKK1 (MEK1) (IC50 = 0.5 nM) and provides neuroprotection by binding to kainate receptors. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 372.42 |
| 分子式 | C21H24O6 |
| 可溶性/溶解性 | Soluble to 25 mM in ethanol with gentle warming and to 100 mM in DMSO |
| CAS号 | 7770-78-7 |
| 参考文献 | Choet al (2003) Arctigenin, a potent inhibitor of MKK1, inhibits lipopolysaccharide (LPS)-inducible nitric oxide synthase expression through inhibition of I-κBα phosphorylation and of p65 nuclear translocation. Exp.Biol.Abstr. 152.2. Choet al (2002) Potent inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by dibenzylbutyrolactone lignans through inhibition of I-κBα phosphorylation and of p65 nuclear translocation. Int.Immunopharmacol. 2 105. PMID: 11789661. Janget al (2002) Arctigenin protects cultured cortical neurons from glutamate-induced neurodegeneration by binding to kainate receptor. J.Neurosci.Res. 68 233. PMID: 11948668. Schroderet al (1990) Differential in vitro anti-HIV activity of natural lignans. Z.Naturforsch.C. 45 1215. PMID: 1965681. |