| 货号 | 1116/50 |
| 别名 | N-(4-Hydroxyphenyl)-5Z,8Z,11Z,14Z-e |
| 供应商 | Tocris |
| 生物活性 | Competitive and selective inhibitor of carrier-mediated anandamide transport (IC50 = 1 μM). Does not activate CB1 receptors or inhibit anandamide hydrolysis but has been shown to activate native and cloned vanilloid receptors (pEC50 = 7.4). Active in vivo. Also available in water soluble emulsion (Cat. No. 1685). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 395.58 |
| 分子式 | C26H37NO2 |
| 可溶性/溶解性 | Soluble to 50 mM in ethanol and to 50 mM in DMSO |
| CAS号 | 198022-70-7 |
| 参考文献 | Zygmuntet al (2000) The anandamide transport inhibitor AM404 activates vanilloid receptors. Eur.J.Pharmacol. 396 39. PMID: 10822052. Piomelliet al (1999) Structural determinants for recognition and translocation by the anandamide transporter. Proc.Natl.Acad.Sci.U.S.A. 96 5802. PMID: 10318965. Beltramoet al (1997) Functional role of high-affinity anandamide transport, as revealed by selective inhibition. Science 277 1094. PMID: 9262477. Calignanoet al (1997) Potentiation of anandamide hypotension by the transport inhibitor, AM 404. Eur.J.Pharmacol. 337 R1. PMID: 9389389. |