| 货号 | 3306/50 |
| 别名 | (E)-8-[2-(3-Chlorophenyl)ethenyl]-3 |
| 供应商 | Tocris |
| 生物活性 | Selective adenosine A2A receptor antagonist and monoamine oxidase B (MAO-B) inhibitor (Ki values are 54 and 28200 nM at rat A2A and A1 receptors respectively and Ki ~ 100 nM at MAO-B). Potently protects against quinolinic acid-induced (Cat. No. 0225) neuronal damage and is neuroprotective in the MPTP model of Parkinson's disease. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 330.77 |
| 分子式 | C16H15CIN4O2 |
| 可溶性/溶解性 | Soluble to 25 mM in DMSO |
| CAS号 | 147700-11-6 |
| 参考文献 | Vloket al (2006) Inhibition of monoamine oxidase B by analogues of the adenosine A2A receptor antagonist (E)-8-(3-chlorostyryl)caffeine (CSC). Bioorg.Med.Chem. 14 3512. PMID: 16442801. Behan and Stone (2002) Enhanced neuronal damage by co-administration of quinolinic acid and free radicals, and protection by adenosine A2A receptor antagonists. Br.J.Pharmacol. 135 1435. PMID: 11906956. Chenet al (2002) 8-(3-Chlorostyryl)caffeine may attenuate MPTP neurotoxicity through dual actions on monoamine oxidase inhibition and A2A receptor antagonism. J.Biol.Chem. 277 36040. PMID: 12130655. |