| 货号 | 3697/50 |
| 别名 | 7-Chloro-4-hydroxyquinoline-2-carbo |
| 供应商 | Tocris |
| 生物活性 | Sodium salt of 7-Chlorokynurenic acid (Cat.No. 0237), an NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 245.59 |
| 分子式 | C10H5CINNaO3 |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| 参考文献 | Bartlettet al (1998) Substituted quinolines as inhibitors of L-glutamate transport into synaptic vesicles. Neuropharmacology 37 839. PMID: 9776380. Kretschmeret al (1995) Behavioral and neurochemical actions of the strychnine-insensitive glycine receptor antagonist, 7-chlorokynurenate, in rats. Eur.J.Pharmacol. 280 37. PMID: 7498252. Donaldet al (1988) Characterization of the [3H]-glycine binding to a modulatory site within the NMDA receptor complex from rat brain. Br.J.Pharmacol. 95892P. Kempet al (1988) 7-Chlorokynurenic acid is a selective antagonist of the glycine modulatory site of the NMDA receptor complex. Proc.Natl.Acad.Sci.USA 856547. |