| 货号 | 0443/50 |
| 别名 | N-[2-(6-Chloro-5-methoxyindol-3-yl) |
| 供应商 | Tocris |
| 生物活性 | Potent melatonin agonist (pKi values are 9.10 and 9.77 for human recombinant MT1 and MT2 receptors respectively). Displays higher affinity for binding to hamster brain membrane and chicken retina than melatonin. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 266.73 |
| 分子式 | C13H15ClN2O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 63762-74-3 |
| 参考文献 | Browninget al (2000) Pharmacological characterization of human recombinant melatonin mt1 and MT2 receptors. Br.J.Pharmacol. 129 877. PMID: 10696085. Dubocovich (1995) Melatonin receptors: are there multiple subtypes? TiPS 16 50. PMID: 7762083. Dubocovich (1988) Luzindole (NO 774): A novel melatonin receptor antagonist. J.Pharmacol.Exp.Ther. 246 902. PMID: 2843633. Duncanet al (1988) 2-[125I]Iodomelatonin binding sites in hamster brain membranes: pharmacological characteristics and regional distribution. Endocrinology 122 1825. PMID: 2834175. |