| 货号 | 5121/50 |
| 别名 | 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-p |
| 供应商 | Tocris |
| 生物活性 | PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) inhibitor; reduces glycolytic flux and suppresses glucose uptake. Inhibits endothelial cell proliferation and causes G2/M cell cycle arrest in vitro. Attenuates vessel sprouting and tumor growth in vivo. Amplifies the antiangiogenic effect of VEGFR blockade. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 210.23 |
| 分子式 | C13H10N2O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Schoorset al (2014) Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis. Cell Metab. 19 37. PMID: 24332967. Clemet al (2008) Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth. Mol.Cancer Ther. 7 110. PMID: 18202014. |