| 货号 | 2137/50 |
| 别名 | 2-[[3-(2,3-Dichlorophenoxy)propyl]a |
| 供应商 | Tocris |
| 生物活性 | Selectively induces apoptosis and downregulates Bcl-XL protein expression in various human cancer cells versus normal cells in vitro. IC50 values are 0.89 and 12.6 μM for LoVo human colon cancer cell line and normal human fibroblasts respectively. Induces p21 expression and S-phase arrest in cancer cells via ERK-mediated pathways. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 300.61 |
| 分子式 | C11H15Cl2NO2.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| CAS号 | 418788-90-6 |
| 参考文献 | Wuet al (2004) Induction of apoptosis and down-regulation of Bcl-XL in cancer cells by a novel small molecule, 2[[3-(2,3-Dichlorophenoxy)propyl]amino]ethanol. Cancer Res. 64 1110. PMID: 14871845. Zhuet al (2004) Induction of S-phase arrest and p21 overexpression by a small molecule 2[[3-(2,3-dichlorophenoxy)propyl]amino]ethanol in correlation with activation of ERK. Oncogene 23 4984. PMID: 15122344. |