Zaragozic Acid A
货号：
17452-5mg 基本售价：
5572.0 元 规格：
5 mg
产品信息
概述| 货号 | 17452-5mg |
| 描述 | Squalene synthase catalyzes the first committed step in cholesterol synthesis, mediating the reductive dimerization of farnesyl pyrophosphate (Item No. 63250) to produce squalene.1 Zaragozic acid A is a fungal metabolite that acts as a reversible competitive inhibitor of squalene synthase (Ki = 78 pM in vitro).2 It dose-dependently reduces cholesterol synthesis in HepG2 cells (IC50 = 6 µM) and inhibits hepatic cholesterol synthesis in mice (ED50 = 0.2 mg/kg).2 Zaragozic acid A also inhibits farnesy transferase (FTase) and geranylgeranyl transferase type I (GGTase I) (IC50s = 216 and 50 nM, respectively).3 |
| 别名 | L-694,599;Squalestatin S1; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Charlton-Menys, V. and Durrington, P.N. Squalene synthase inhibitors: Clinical pharmacology and cholesterol-lowering potential. Drugs 67(1), 11-16 (2007).
2.Bergstrom, J.D.,Kurtz, M.M.,Rew, D.J., et al. Zaragozic acids: A family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase. Proceedings of the National Academy of Sciences of the United States of America 90(1), 80-84 (1993).
3.Gibbs, J.B.,Pompliano, D.L.,Mosser, S.D., et al. Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo. The Journal of Biological Chemisty 268(11), 7617-7620 (1993).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 690.7 |
| 分子式 | C35H46O14 |
| CAS号 | 142561-96-4 |
| 稳定性 | ≥ 2 years |
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