| 货号 | 13866-50ug |
| 描述 | Protein arginine methyltransferases (PRMTs) are a family of enzymes with highly conserved catalytic domains that catalyze the transfer of a methyl group from S-adenosyl-L-methionine to a specific arginine residue in a target protein. PRMT6 is a nuclear type-1 PRMT, catalyzing the formation of ω-NG-monomethylarginine and asymmetric ω-NG,NG-dimethylarginine on both histone and non-histone targets.1,2,3 Histone H3 methylation of arginine 2 (H3R2) is a repressive transcriptional mark primarily catalyzed by PRMT6.4 H3R2 dimethylation antagonizes the binding of effector proteins sensitive to H3K4 methylation, such as the Mixed Lineage Leukemia complex methyltransferase.5 Non-histone targets of PRMT6 include the nuclear high-mobility group protein HMGA1a, a protein important in several processes relating to the maintenance of DNA integrity.3 |
| 别名 | Histone Arginine N-methyltransferase PRMT6;HRMT1L6;Protein Arginine Methyltransferase 6; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Frankel, A.,Yadav, N.,Lee, J., et al. The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity. The Journal of Biological Chemisty 277(5), 3537-3543 (2002). 2.Wolf, S.S. The protein arginine methyltransferase family: An update about function, new perspectives and the physiological role in humans. Cellular and Molecular Life Sciences 66, 2109-2121 (2009). 3.Miranda, T.B.,Webb, K.J.,Edberg, D.D., et al. Protein arginine methyltransferase 6 specifically methylates the nonhistone chromatin protein HMGA1a. Biochemical and Biophysical Research Communications 336(3), 831-835 (2005). 4.Iberg, A.N.,Espejo, A.,Cheng, D., et al. Arginine methylation of the histone H3 tail impedes effector binding. The Journal of Biological Chemisty 283(6), 3006-3010 (2008). 5.Guccione, E.,Bassi, C.,Casadio, F., et al. Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive. Nature 449, 933-937 (2007). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥60% |
| 稳定性 | ≥ 1 year |
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