| 货号 | 16333-25mg |
| 描述 | β-Nicotyrine is an alkaloid metabolite of nicotine as well as a major product of its pyrolysis.1,2 It binds comparably to two cytochrome P450 (CYP) isoforms, CYP2A6 and CYP2A13 (Kis = 7.5 and 5.6 µM, respectively), which are prominently involved in the metabolism of xenobiotics in the airways.3 However, β-nicotyrine appears to more effectively inactivate CYP2A6, leaving only 49% activity after a 10 minute exposure with 20 µM β-nicotyrine, as opposed to 87% remaining activity for CYP2A13 treated identically.4 Presumably through this effect, β-nicotyrine inhibits DNA strand breaks induced by the genotoxic tobacco metabolite (4-(methylnitrosamino)-1-(2-pyridyl)-1-butanone), which is bioactivated by CYP2A isoforms.5 |
| 别名 | α-Nicotyrine;NSC 127943;NSC 407276; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Swain, M.L.,Eisner, A.,Woodward, C.F., et al. Ultraviolet absorption spectra of nicotine, nornicotine and some of their derivatives. Journal of the American Chemical Society 71(4), 1341-1345 (1949). 2.Clayton, P.,Lu, A. and Bishop, L. The pyrolysis of (−)-(S)-nicotine: Racemization and decomposition. Chirality 22(4), 442-446 (2010). 3.Stephens, E.S.,Walsh, A.A. and Scott, E.E. Evaluation of inhibition selectivity for human cytochrome P450 2A enzymes. Drug Metabolism and Disposition 40(9), 1797-1802 (2012). 4.Kramlinger, V.M.,von Weymarn, L.B. and Murphy, S.E. Inhibition and inactivation of cytochrome P450 2A6 and cytochrome P450 2A13 by menthofuran, β-nicotyrine and menthol. Chemico-Biological Interactions 197(2-3), 87-92 (2012). 5.Ordonez, P.,Sierra, A.B.,Camacho, O.M., et al. Nicotine, cotinine, and β-nicotyrine inhibit NNK-induced DNA-strand break in the hepatic cell line HepaRG. Toxicol.In Vitro 28(2014), 1329-1337 (2014). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 158.2 |
| 分子式 | C10H10N2 |
| CAS号 | 487-19-4 |
| 稳定性 | ≥ 2 years |
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