| 货号 | 2157/1 |
| 别名 | [[(1R,2R,3S,4R,5S)-4-[6-Amino-2-(me |
| 供应商 | Tocris |
| 生物活性 | Highly potent, selective P2Y1 receptor agonist (EC50 = 0.4 nM). Displays no activity at P2Y12 receptors and only very low agonist activity at P2Y13 receptors (at concentrations up to 1 μM). Increases the upregulation of NTPDase1 by ATPγS. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 549.28 |
| 分子式 | C13H16N5O9P2SNa3 |
| 可溶性/溶解性 | Soluble in water (supplied pre-dissolved at a concentration of 10mM) |
| CAS号 | 436847-09-5 |
| 参考文献 | Luet al (2007) Stimulation of the P2Y1 receptor up-regulates nucleoside-triphosphate diphosphohydrolase-1 in human retinal pigment epithelial cells. J.Pharmacol.Exp.Ther. 323 157. PMID: 17626796. Chhatriwalaet al (2004) Induction of novel agonist selectivity for the ADP-activated P2Y1 receptor versus the ADP-activated P2Y12 and P2Y13 receptors by conformational constraint of an ADP analog. J.Pharmacol.Exp.Ther. 311 1038. PMID: 15345752. Raviet al (2002) Adenine nucleotide analogues locked in a northern methanocarba conformation: enhanced stability and potency as P2Y1 receptor agonists. J.Med.Chem. 45 2090. PMID: 11985476. |