IKK2 Inhibitor VI
货号：
17276-5mg 基本售价：
5530.0 元 规格：
5 mg
产品信息
概述| 货号 | 17276-5mg |
| 描述 | Inhibitor of NF-κB kinase 2 (IKK2, also known as IKKβ) acts as part of an IKK complex in the canonical NF-κB pathway, phosphorylating inhibitors of NF-κB (IκBs) to initiate signaling. NF-κB signaling can also occur through a non-canonical, IKK/IκB-independent pathway. IKK2 Inhibitor VI is a potent, cell-permeable, reversible inhibitor of IKK2 (IC50 = 13 nM).1 It is used to evaluate the role of the canonical, IκB-dependent NF-κB signaling pathway in cellular responses.2,3 |
| 别名 | 5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Baxter, A.,Brough, S.,Cooper, A., et al. Hit-to-lead studies: The discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors. Bioorganic & Medicinal Chemistry Letters 14, 2817-2822 (2004).
2.McNamara, L.A.,Ganesh, J.A., and Collins, K.L. Latent HIV-1 infection occurs in multiple subsets of hematopoietic progenitor cells and is reversed by NF-κB activation. Journal of Virology 86(17), 9337-9350 (2012).
3.Punj, V.,Matta, H., and Chaudhary, P.M. A computational profiling of changes in gene expression and transcription factors induced by vFLIP K13 in primary effusion lymphoma. PLoS One 7(5), 1-15 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 261.3 |
| 分子式 | C12H11N3O2S |
| CAS号 | 354811-10-2 |
| 稳定性 | ≥ 2 years |
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