Irisin (human recombinant)
货号：
11451-100ug 基本售价：
5530.0 元 规格：
100 ug
产品信息
概述| 货号 | 11451-100ug |
| 描述 | Physical exertion and exercise are the primary defenses against obesity, insulin resistance, and diabetes. The transcriptional co-activator peroxisome proliferator-activated receptor C coactivator 1α (PGC-1α), regulates mitochondrial biogenesis and function.1 Expression of the membrane protein Fibronectin type III domain-containing protein 5 (FNDC5) is stimulated in muscle by PGC-1α in response to exercise. FNDC5 is proteolytically cleaved and secreted as the hormone peptide irisin (named after the Greek goddess messenger Iris). Irisin has been shown to convert white adipose fat to brown adipose fat upon physical exertion. Brown adipose fat allows for mitochondrial uncoupling leading to thermogenetic programs and heat expenditure.2 The physiological responses induced by the effects of irisin have the potential to increase weight loss and reduce insulin resistance and obesity. |
| 别名 | Fibronectin Type III Domain 5;FNDC5;FRCP2;PeP; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kelly, D.P. Irisin, light my fire. Science 336, 42-43 (2012).
2.Boström, P.,Wu, J.,Jedrychowski, M.P., et al. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 481, 463-468 (2012).
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| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥90% estimated by SDS-PAGE |
| CAS号 | 9037-90-5 |
| 稳定性 | ≥ 1 year |
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