| 货号 | 10785-50ug |
| 描述 | Protein Arginine Deiminases (PADs) are guanidino-modifying enzymes belonging to the amidinotransferase superfamily and are designated PAD1-4 and PAD6. PAD enzymes catalyze the conversion of specific arginine residues to citrulline in a calcium-dependent manner. All enzymes are cytosolic except for PAD4 which is localized in the nucleus.1 PAD2 is the most widely expressed member and also the most conserved across mammalian species, implying it is the ancestral homologue of the PADs.2 Overexpression of PAD2 results in myelin loss in a transgenic model, potentially linking PAD2 activity to multiple sclerosis.3 It has also been shown to modify vimentin and β/γ-actin, potentially aggravating the autoantigen response in rheumatoid arthritis.4,5 PAD2 may also play a role in transcriptional regulation, as it has been shown capable of citrullinating histones, particularly H3 during mammalian reproductive cycles, when it is transcriptionally activated in the nucleus.6 |
| 别名 | PADI2;PAD-H19;Peptidylarginine Deiminase 2;Protein Arginine Deiminase 2; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Shirai, H.,Blundell, T.L. and Mizuguchi, K. A novel superfamily of enzymes that catalyze the modification of guanidino groups. Trends in Biochemical Sciences 26(8), 465-468 (2001). 2.Vossenaar, E.R.,Zendman, A.J.,van Venrooij, W.J., et al. PAD, a growing family of citrullinating enzymes: Genes, features and involvement in disease. BioEssays 25(11), 1106-1118 (2003). 3.Musse, A.A.,Li, Z.,Ackerley, C.A., et al. Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system. Dis.Model Mech. 1(4-5), 229-240 (2008). 4.Vossenaar, E.R.,Radstake, T.R.D.,van der Heiden, A., et al. Expression and activity of citrullinating peptidylarginine deiminase enzymes in monocytes and macrophages. Ann. Rheum. Dis. 63(4), 373-381 (2004). 5.Darrah, E.,Rosen, A.,Giles, J.T., et al. Peptidylarginine deiminase 2, 3 and 4 have distinct specificities against cellular substrates: Novel insights into autoantigen selection in rheumatoid arthritis. Annals of the Rheumatic Diseases 71(1), 92-98 (2012). 6.Zhang, X.,Bolt, M.,Guertin, M.J., et al. Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor a target gene activation. Proceedings of the National Academy of Sciences of the United States of America 109(33), 13331-13336 (2012). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥95% (estimated by SDS-PAGE) |
| 稳定性 | ≥ 1 year |
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