| 货号 | 71610-50mg |
| 描述 | CD437 is the prototypical adamantyl arotinoid of the retinoid-related molecule family that acts as a selective agonist of retinoic acid receptor (RAR)γ (Kds = 6.5 μM, 2.5 μM, and 77 nM for RARα, β, and γ, respectively).1,2 CD437 is cytotoxic to the acute myeloid leukemia cell line NB4 (EC50 = 0.17 μM), inducing DNA damage by producing DNA double strand breaks.3 CD437 also induces cell cycle arrest and apoptosis in various other cancer cells including melanoma, breast, non-small lung, and prostate cancer cells through RAR-dependent and -independent signaling pathways.4,5 |
| 别名 | AHPN; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Pérez-Rodríguez, S.,Ortiz, M.A.,Pereira, R., et al. Highly twisted adamantyl arotinoids: Synthesis, antiproliferative effects and RXR transactivation profiles. European Journal of Medicinal Chemistry 44(6), 2434-2446 (2009). 2.Bernard, B.A.,Bernardon, J.M.,Delescluse, C., et al. Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor γ. Biochemical and Biophysical Research Communications 186(2), 977-983 (1992). 3.Valli, C.,Paroni, G.,Di Francesco, A.M., et al. Atypical retinoids ST1926 and CD437 are S-phase-specific agents causing DNA double-strand breaks: Significance for the cytotoxic and antiproliferative activity. Molecular Cancer Therapeutics 7(9), 2941-2954 (2008). 4.Fontana, J.A. and Rishi, A.K. Classical and novel retinoids: Their targets in cancer therapy. Leukemia 16(4), 463-472 (2002). 5.Jin, F.,Liu, X.,Zhou, Z., et al. Activation of nuclear factor-κB contributes to induction of death receptors and apoptosis by the synthetic retinoid CD437 in DU145 human prostate cancer cells. Cancer Research 65(14), 6354-6363 (2005). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 398.5 |
| 分子式 | C27H26O3 |
| CAS号 | 125316-60-1 |
| 稳定性 | ≥ 2 years |
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