| 货号 | 1608/500U |
| 别名 | cyclo(31-34)[D-Phe12,Nle21,38,Glu31, Lys34]Ac-hCRF (4-41) |
| 供应商 | Tocris |
| 生物活性 | Potent and selective corticotropin releasing factor receptor-1 (CRF1) agonist (Ki values are 1.5 and 224 nM for CRF1 and CRF2 receptors respectively). Increases ACTH levels and increases faecal pellet output in vivo following i.p. administration. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 4472.24 |
| 分子式 | C203H337N57O |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| 序列号 | PPISLDLTFHLLREVLEXARAEQLAQQEHS (Modifications: Pro-1 = N-terminal Ac, X = Nle, Glu-28 = γ-Glu, Lys-31 = ε-Lys, Cyclized = Glu-28 - Lys-31, Ile-38 = C-terminal amide) |
| 参考文献 | Bruchaset al (2009) CRF1-R activation of the dynorphin/kappa opioid system in the mouse basolateral amygdala mediates anxiety-like behavior. PLoS One. 4 e8528. PMID: 20052275. Rivieret al (2007) Stressin1-A, a potent corticotropin releasing factor receptor 1 (CRF1)-selective peptide agonist. J.Med.Chem. 50 1668. PMID: 17335188. Rivieret al (2002) Receptor-selective corticotropin releasing factor analogs. Endocrin.Soc.Abstr. P2-50. |