| 货号 | 10011236-96Well |
| 描述 | C-Reactive Protein (CRP) is a 224 amino acid protein that is synthesized primarily by hepatocytes, and to a lesser extent adipocytes. CRP plasma levels increase ~1,000-fold in response to acute and chronic inflammatory conditions, making it a useful gauge of inflammation in a wide range of physiological and pathological conditions.1 Normal levels of serum CRP (0.64 µg/ml) do not differ between healthy adult men and women, but tend to increase slightly with age.2 High plasma CRP concentrations (>3 µg/ml) are associated with an increased risk for atherosclerosis.3 CRP has been implicated as a contributor to atherogenesis by modulating endothelial function, stimulating coagulation, inducing the expression of ICAM-1, VCAM-1, and E-selectin, mediating uptake of LDL into macrophages, and destabilizing plaques.1,4,5,6,7,8,9 In addition, CRP can bind in a calcium-dependent manner to phosphocholine on microbes, act as a ligand for specific receptors on phagocytic leukocytes, mediate activation of monocytes and macrophages via IL-6, TNF-α and other cytokines, and assist in the complement pathway.1,10,11,12 Cayman’s CRP (human) ELISA Kit is an immunometric assay which can be used to measure CRP in plasma without prior sample purification. The standard curve spans the range of 46.9-3,000 pg/ml with a limit of detection of approximately 46.9 pg/ml. |
| 别名 | CRP (human) EIA Kit; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Volanakis, J.E. Human C-reactive protein: expression, structure, and function. Molecular Immunology 38, 189-197 (2001). 2.Macy, E.M.,Hayes, T.E. and Tracy, R.P. Variability in the measurement of C-reactive protein in healthy subjects: implications for reference intervals and epidemiological applications. Clinical Chemistry 43(1), 52-58 (1997). 3.Ridker, P.M. Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Circulation 107, 363-369 (2003). 4.Pasceri, V.,Willerson, J.T. and Yeh, E.T.H. Direct proinflammatory effect of C-reactive protein on human endothelial cells. Circulation 102, 2165-2168 (2000). 5.Tracy, R.P. Inflammation in cardiovascular disease cart, horse, or both? Circulation 97, 2000-2002 (1998). 6.Fichtlscherer, S.,Rosenberger, G.,Walter, D.H., et al. Elevated C-reactive protein levels and impaired endothelial vasoreactivity in patients with coronary artery disease. Circulation 102, 1000-1006 (2000). 7.Zwaka, T.P.,Hombach, V. and Torzewski, J. C-reactive protein-mediated low density lipoprotein uptake by macrophages. Implications for atherosclerosis. Circulation 103, 1194-1197 (2001). 8.Howitz, K.T.,Bitterman, K.J.,Cohen, H.Y., et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425, 191-196 (2003). 9.de Ferranti, S. and Rifai, N. C-reactive protein and cardiovascular disease: a review of risk prediction and interventions. Clinica Chimica Acta 317, 1-15 (2002). 10.Marnell, L.L.,Mold, C.,Volzer, M.A., et al. C-reactive protein binds to Fc g RI in transfected COS cells. Journal of Immunology 155, 2185-2193 (1995). 11.Szalai, A.J.,van Ginkel, F.W.,Wang, Y., et al. Complement-dependent acute-phase expression of C-reactive protein and serum amyloid P-component. Journal of Immunology 165, 1030-1035 (2000). 12.Ganapathi, M.K.,Rzewnicki, D.,Samols, D., et al. Effect of combinations of cytokines and hormones on synthesis of serum amyloid A and C-reactive protein in HEP 3B cells. Journal of Immunology 147(4), 1261-1265 (1991). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | 4 |
| 稳定性 | ≥ 6 months |
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