| 货号 | 90001845-10mg |
| 描述 | The synthetic oleanane triterpenoid CDDO (Item No. 81035) is a Nrf2 activator that inhibits proliferation and induces differentiation and apoptosis in various cancer cells. CDDO-TFEA is a trifluoroethylamide derivative of CDDO with enhanced ability to cross the blood brain barrier. It has been shown to enhance Nrf2 expression and signaling in various models of neurodegeneration, including those that simulate multiple sclerosis, amyotrophic lateral sclerosis, and Huntington’s disease.1,2,3 CDDO-TFEA induces apoptosis of Ewing’s sarcoma and neuroblastoma cell lines, preventing colony formation at IC50 values ranging from 85-170 nM.4 |
| 别名 | CDDO-Trifluoethyl Amide;RTA 404;TP-500; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Pareek, T.K.,Belkadi, A.,Kesavapany, S., et al. Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis. Sci.Rep. 1, 201 (2011). 2.Neymotin, A.,Calingasan, N.Y.,Wille, E., et al. Neuroprotective effect of Nrf2/ARE activators, CDDO-ethylamide and CDDO-trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis. Free Radical Biology & Medicine 51(1), 88-96 (2011). 3.Stack, C.,Ho, D.,Wille, E., et al. Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington’s disease. Free Radical Biology & Medicine 49(2), 147-158 (2010). 4.Alabran, J.L.,Cheuk, A.,Liby, K., et al. Human neuroblastoma cells rapidly enter cell cycle arrest and apoptosis following exposure to C-28 derivatives of the synthetic triterpenoid CDDO. Cancer Biology and Therapy 7(5), 709-717 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 572.7 |
| 分子式 | C33H43F3N2O3 |
| CAS号 | 932730-52-4 |
| 稳定性 | ≥ 2 years |
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